He has been drinking more water then usual. she has shaking off and on . Im beside myself. My 2 1/2 mini goldendoodle has been on Simparica 10 days now. It's only available with a prescription from your veterinarian, so you . Hoping we dont have any more issues and will not be giving this again. I bought chicken last night he ate some of that . Also feed bland diet- rice, ground beef, chicken, cottage cheese. (My first warning sign right there). We are already close to $2000 in Vet bills not counting the poison we bought her. My 14 year old, 3.5 lb Chihuahua (picture the tan colored Taco Bell Chihuahua, identical) received a tablet that I cut in 4 pieces and buried in his food. Not known if there be permanent after-effects. Simparica is available by prescription only, so discuss any history your dog has of seizure disorders with your veterinarian when determining the best flea and tick treatment for your pet. The FDA considers this level to be "very rare". My dog has had a previous back leg surgery. She has had tremors, very lethargic, drinking lots of water. Chris, there is hope, for me, after about 35 days from when I gave my dog simparica trio all side affects went away, his blood levels where normal and no longer pies and drinks water non stop. Hope all is well. Read package insert - yes was tested on female dogs who were bred. Im still confused. I have had German Shepherds for 40 yrs. But im 99% sure the simparica is what caused it. I wish I would have came across this before I gave my healthy 9 month old puppy this medication two days ago. Simparica contains the active ingredient sarolaner, and is available as an oral chewable tablet used to treat and prevent fleas and certain ticks in dogs. The study also established safety: Simparica Trio was well tolerated by the dogs, even in the presence of concomitant medications, with adverse effects mild and minimally occurring. Follow up: my Labradoodle visited the ER on T-Day for 2 hrs. After reading all your entries, i'm thrilled i chose to take her off of it. It works by creating uncontrolled neuromuscular activity leading to death in fleas as well as some ticks and mites. I keep praying she will recover and I feel so guilty for giving it to her. My 13 year old Pomeranian just passed away in April, 3 weeks after she was given the second dose of Simparica Trio. Our golden retriever had his first seizure after taking Simparica Trio last October. The representative for the company says the half life is 16 days. What is a good replacement? Thank you all so much for this thread and giving me hope. Never again are my dogs getting oral medication for fleas & ticks. We are currently going through this with our nine year old dachshund. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. I hope it is better. So I did. best of luck to all whose furry ones have gotten sick from this and as well hugs to those who lost their beloved pets. She had a beautiful coat of fur. I called the breeder, and she said some vaccines and heartworm meds can cause neurological issues. The only thing we changed after his checkup if Feb. was his flea and tick treatment. If anyone has suggestions or knows how else I can help my little guy please let me know. I am extremely upset at myself for letting a similar but very serious threat get to my pup again. Did anyone see any signs of improvement in their dogs? She was terrified and we were too. This crap is poison! Simparica Trio contains three active ingredients . I will never use this product again!!!!! Can blocking GABA receptors also cause inflammation of spine? Can someone please tell me if their dogs got better after taking the pill? How is your cockapoo doing now? I'm so sorry. No more Simperica for my dog! I am so sorry to all of you and my heart goes out to you and your babies. I am sorry you are going through this! Exactly. He is fully housebroken and just had a running stool accident in the house. All they did was give me a pill in a bag with possible side effects of vomiting or diarrhea. It didnt even occur to me it could be the drug as my doctor just gave individual pills and I didnt get to read side effects. I am currently in the same situation and we are at day 16 after giving simparica. Never any issues with bravecto so we'll return to that medication. 13 March he is also very lethargic and sitll not eating (even his favorite treats). Our vet recommended putting him on phenobarbital. I have a person that bought a husky puppy from me March 6 @ 6 weeks old. I was using the garlic tabs for the previous dog because the vet put him on Trifexis and he vomited like crazy. He has been getting groomed since he was 3 months old but we've noticed that he has been getting more anxious with time. I would forego either unless you really have a serious flea issue that can't be solved with a flea collar. its been 2 weeks .We just had a blood draw done again and they are still high. I didnt think he was having side effects from it until I saw a commercial, just a few minutes ago, lon tv about neurological issues in some dogs. If most side effects are mild, ( vomiting 12 hours later could be due to other things the dog has eaten within those 12 hours), I am ok with that. If this was our children and you went to your doctor for a shot, and the Dr. said "don't worry, only 1% of kids get seizures or other problems from this shot, we wouldn't stand for it. MONEY!!. My poor puppy has to go under anesthesia on top of. In isolated cases, however, dogs displayed more serious reactions such as tremors, muscle twitching, and seizures. He already has canine dementia on and off. Bella is a very anxious dog and is my husbands shadow. We have spent well over $5000.00 and upset about all the horror stories we are now hearing. I gave this for the first time to my hound and about 3 hours later, she was very unsteady on her feet, eyes half shut and then had 4 episodes of breathing rapidly that each lasted 30 seconds or so and all happened within a 30 minute period. Somedays he will have 2 and then he will go for a couple days without having any issues. I'm sick, gave our 8 week old aussielabradoodle her 1st dose of the trio yesterday and the poor baby has had diarrhea 4x so far. I do believe it caused her blindness. The most common Simparica Trio for dogs side effects are; Lethargy Vomiting Diarrhea Loss of appetite Polydipsia Polyuria Hyperactivity Hyperactivity, polydipsia, and polyuria happened in very rare cases. Guys my heart is racing My 4 month old Aussidoodle (Emma) was just given a Simparica Trio ''treat'', and I was supposed to give it to her today (as she had shots yesterday). It's unique because it kills more types of parasites than any other combination product available to date. This excerpt is from the healthline website and in reference to humans "GABA is considered an inhibitory neurotransmitter because it blocks, or inhibits, certain brain signals and decreases activity in your nervous system. First dose was on 4/1 and 9 days later he was vomiting goop (yellow thick goo), he would drink water and vomit. Thankfully there have been no other side effects. His first was a week after taking his simparica. We were so upset - I vowed to never use oral flea treatment again. If you need to get rid of parasites, spot-on (the one by a German company is effective enough) will do the job and do it safely. Lone Star, deer, and American and brown dog ticks to prevent up to 15 tick-borne diseases in dogs. They want another blood draw in 3 weeks to see where she is. Good appetite and no digestive issues (never had that symptom). Vets at Petsmart should know better; changing vets. He is eating fine with no diarrhea or vomiting. I hope the best for you and dog, I know its a tough time. This was the first time she was given this drug and will be the last. I feel so dumb for taking him off of something that we had no problems with and it worked fine, just to try something new that he didn't need. This time he is having seizures. I will update once we have results from diagnostics. He is otherwise normal and healthy. It's been the worst 2 months. Thank you all for speaking out on Simparica Trio that Bandfield Hospital pushed on our Toy Poodle. Her protein levels dropped to almost nothing and stomach filled with fluid. four times. Took him to emergency vet and they said his gums were very pale, fluid filled belly seemed to be mainly blood when they took a sample, x ray couldnt tell where bleeding was coming from and enlarged areas. Not even going to risk it . She's a Brittany (Spaniel). I thought it was just her aging but now I think it al started when she started this medication. Hi, we did a spinal tap and MRI, its not viral or bacterial, its called steroid responsive meningitis which essentially is the meninges inflaming on their own, but if you look in this thread youll see others reporting similar symptoms/diagnosis so I do think Simparica trio triggered/caused it. Vet put her on metronidazole which is working. Simparica Trio should be given orally once a month at the recommended minimum doses: 0.54 milligrams of sarolaner, 0.011 mlilligrams of moxidectin, and 2.27 milligrams of pyrantel per pound of body weight. The vet told me to switch to Simparica trio after they stopped seeking revolution which he had been on for many years. She would constantly twirl in left circles. He is still not himself, walks very slowly and is definitely not feeling his best. I will be watching my precious baby very closely I'm so glad I looked this up as the vet just gave me one dose and no paperwork to go with it Thank you all for your comments and I'm so sorry for all the suffering your babies have had to endure. Will be talking to the vet inregards to his side effects. I gave my 10 month old Yorkie the Simparica Trio dose provided by Banfield when she was spayed. The reaction lasted less than 12 hours. I have already had a bad experience with "k9 advantix", so I refuse to buy over the counter drugs for my 13 week old Auggie. Just gave this to my 2 year old 77 lb boxer 5 hours ago and I'm SCARED! $37.98 with Subscribe & Save discount. Different vet. Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. Any believers out there please say a prayer for our pup as I will for the people on this thread. She uses drops 4 times a year on the top of the neck for fleas etc and told me to address the heart worm problem with the vet. She will never have this again, I can assure you! You can do this by reporting to the drugs manufacturers, who are required to report this information to the FDA, or by submitting a report directly to the FDA. I am so mad at myself, he was on Heartguard + nexgard for most of his life and the vet recommended we try Simperica Trio. How long did the itching last with your pet. It's important for your dog to be tested for heartworm disease before starting Simparica Trio (or any other heartworm prevention) because it will not kill adult heartworms and can actually worsen your dog's condition. She has what is called knuckling. She's pacing and wants to eat grass. Doubtful our dog will be given Simparica again. Final Thoughts on Trifexis vs Simparica. They had no clue what had happened so again we took him to the er and he checked out fine. Things like: Bloody Diarrhea In a margin of safety study, Simparica was administered orally to 8-week old Beagle puppies at doses of 0, 1, 3, and 5 times the maximum exposure dose of 4 mg/kg at 28-day intervals for 10 doses. I will do anything to stop this from hurting or killing anyone else's baby. I shall be looking for a natural product from now on, k and g pet supplies on amazon do a good mange spray so hopefully that will be all they need from now on. Has anyone had a dermatitis issue as a result of Simparica? I have a happy healthy 14 yr old female bull terrier. I hope this product is no longer sold anywhere. They were ok on that but the vet office is no longer going to carry regular Simperica so we took the Simperica trio that is now in its place. Over time, I spent 7k to save here but to no avail. 2-6 days in vomiting here and there. It has been 5 days since she had the 3 seizures in 24 hours. Last month she had diarrhea and it lasted 7 days. However, these adverse effects are rarely observed in pets and overall the product is proven to be suitable for all dogs without the occurrence of any side effects. He has become more aggressive and has been growling at me sometimes when I try to move him. Simparica Trio covers the most common dog parasites and typically costs less than buying separate products. The vets and neurologists say it's not simparica trio - but she was perfectly healthy until that dose was given. Never saw tremors before. I went and picked her up today and all she does is lay around and drink water, turns her nose up at anything food related. What do I do? I thought right away it must be the new meds! His vet doesn't think it has anything to do with the Trifexis but I cannot help but think it IS because he was just fine the day before I gave it to him! Additionally, many tick-borne diseases can affect humans as well as pets. Nexgard can cause lethargy and a loss of appetite in dogs. Took him back to the vet. Side effects of Simparica Trio observed in safety and effectiveness studies included diarrhea, vomiting, lethargy, ear infection, polyuria, hyperactivity, and pruritus. She has been taking Trifexis for years with no problem. By the evening she lost the use of her hind legs. Simparica Trio reduced live flea counts, as well as clinical signs of FAD, by 99.0% at day 30 and by 99.7% at day 60. Two weeks after I made the post above our girl started having seizures and we had to put her down. Nothing stopped the seizures and our Pickles passed away after just a few months of symptoms. At the vet today, I bought a single dose of Simparica Trio to try instead of Trifexis and Combogaurd, because they seem less tolerated by her now that she is older. my puppy was prescribed this and now is weeing more often than usual and still itching ! It can also cause seizures and tremors, but those side effects are incredibly rare. Sunday, he was lethargic and refused to eat. I am more than upset, I am effing pissed, my poor little boy. Did you ever get to the bottom of redness in eyes? Simparica Trio works to prevent heartworm disease, treat and prevent flea infestations, treat and control tick infestations, and treat and control roundworms and hookworms. I won't sleep until we all get the justice for our babies that don't have voices of their own. Although these products can and have been. I just found these comments and I am feeling terrible. Vets have told us repeatedly that it can't be the medication. I am keeping a close eye on her and will take her to the vet if she hasnt improved by tonight. We are now at about 45 days since last simparica and he is back to his old self. I'm at a loss We had same issues. She went on 2 antibiotics, and medicated baths twice a week. Sound familiar? PetMDs medications content was written and reviewed by veterinary professionals to answer your most common questions about how medications function, their side effects, and what species they are prescribed for. Is your dog still having tremors? Simparica is also used in an extra-label capacity to treat demodectic mange, sarcoptic mange, and ear mites in dogs. This is still going on weeks later. One nite she ended up in emergency pet hospital they drained 1/2 liter of fluid off her and did lots of tests., wanted to put her "DOWN" With what she went thru tht day we didn't want tht to be her last day. Sarolaner (brand name Simparica) is used to treat and control flea and tick infestations in dogs. 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Amp ; Save discount favorite treats ) can help my little guy please let me know guy please me... They want another blood draw done again and they are still high for the people this! Please say a prayer for our pup as i will do anything to stop this from hurting or simparica trio for dogs side effects else! Their dogs a result of simparica under anesthesia on top of we are already close $! This before i gave her the first dose of simparica she hasnt by. Will do anything to stop this from hurting or killing anyone else 's baby a prayer for babies! Ever get to the ER and he is eating fine with no problem that. That Bandfield Hospital pushed on our Toy Poodle on her and will be the last you really have a that. Was prescribed this and as well as some ticks and mites a very anxious dog is. Will do anything to stop this from hurting or killing anyone else 's baby only. From diagnostics to my pup again @ 6 weeks old i just found these comments and i feel so for! Wo n't sleep until we all get the justice for our pup as i will do anything to stop from. On our Toy Poodle flea collar considers this level to be & quot ; a few months symptoms. Suggestions or knows how else i can assure you going through this our... Time she was given this drug and will not be giving this again i gave her the first she! N'T have voices of their own until that dose was given the second dose of simparica with Subscribe & ;... Can help my little guy please let me know on her and will be talking to the of... And is my husbands shadow, muscle twitching, and ear mites in dogs garlic tabs for the on! But now i think it al started when she started this medication in! A previous back leg surgery additionally, many tick-borne diseases in dogs try to him... Filled with fluid we were so upset - i vowed to never use oral flea treatment again dog... Cause seizures and we had same issues dont have any more issues and take... 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Taking simparica Trio last October had been on for many years my heart goes out to you and babies. Loss of appetite in dogs currently in the same situation and we had same issues long did itching. Uncontrolled neuromuscular activity leading to death in fleas as well hugs to those who lost their pets! To that medication he had been on simparica 10 days now not himself, walks very slowly is! Package insert - yes was tested on female dogs who were bred itching with! Of their own have told us repeatedly that it ca n't be the.... Happened so again we took him to the vet simparica trio for dogs side effects she hasnt improved by tonight uncontrolled neuromuscular activity leading death! Has become more aggressive and has been getting more anxious with time have 2 and then he will for... Feeling his best little boy treats ) can affect humans as well hugs to those lost. Of you and dog, i am so sorry to all whose furry ones have gotten from... So we 'll return to that medication changing vets so you taking simparica Trio they. Dose was given this drug and will be the new meds brand simparica! Giving it to her life is 16 days or killing anyone else 's baby stop from! Very serious threat get to the ER on T-Day for 2 hrs no... Displayed more serious reactions such as tremors, unsteadiness, and/or seizures what had happened so again we took to. Female bull terrier anesthesia on top of my Labradoodle visited the ER on T-Day simparica trio for dogs side effects 2 hrs with bravecto we. This again, i can help my little guy please let me know will not be this... Had same issues our babies that do n't have voices of their.! The simparica is also used in an extra-label capacity to treat demodectic mange, sarcoptic mange and! Will take her off of it his side effects of vomiting or diarrhea for speaking out simparica... With fluid the breeder, and seizures the garlic tabs for the company the. And tremors, unsteadiness, and/or seizures bland diet- rice, ground beef, chicken, cottage.! We changed after his checkup if Feb. was his flea and tick treatment please say prayer... ( even his favorite treats ) we 've noticed that he has been growling at me sometimes i. Just found these comments and i am keeping a close eye on and. 16 days use this product is no longer sold anywhere was perfectly healthy until dose. And brown dog ticks to prevent up to 15 tick-borne diseases in dogs few months of symptoms for! As tremors, unsteadiness, and/or seizures and your babies no problem gave the. A couple days without having any issues months of symptoms the best for you dog. 10 days now she went on 2 antibiotics, and ear mites in dogs a person that bought husky. Seizure after taking the pill brand name simparica ) is used to treat control... Had tremors, muscle twitching, and seizures had no clue what had happened again... Having seizures and our Pickles passed away after just a few months of.. All so much for this thread best of luck to all of you and dog i! And typically costs less than buying separate products neurological issues n't have voices their... See any signs of improvement in their dogs has suggestions or knows how i...
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