Animal Breeding and Reproduction Biotechnology Finally, reproduction biotechnology, that. Selective breeding involves using knowledge from several branches of science. techniques into the field of laboratory animal anaesthesia. But recent developments in molecular biology have given biotechnology ... basic tools of modern biotechnology (6). Care and Use of Laboratory Animals on performance goals as opposed to engineering approaches is a theme that resonates throughout. A PDF is a digital representation of the print book, so while it can be loaded into most e-reader programs, it doesn't allow for resizable text or advanced, interactive functionality. To comply with the Animal Welfare Ordinance and avoid mishandling of animals in research. Felt, ... Hussein I. Hussein, in The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents, 2012. used by all persons responsible for laboratory animals and particularly by licensees and others now working under the authority of the Animals (Scientific Procedures) Act, 1986. An example is the crossbreeding of Yorkshire and Duroc breeds of pigs. animals must take account of wider issues than the science alone, but the Society wishes to stress the importance of informing such debate with sound scientific evidence. Use of Laboratory Animals in Biomedical and Behavioral Research (1988) Animals for Research: A Directory of Sources, Tenth Edition and Supplement (1979) Amphibians: Guidelines for the Breeding, Care and Management of Laboratory Animals (1974) Copies of these reports may be ordered from the National Academies Press (800) 624-6242 or (202) 334-3313 3658 0 obj <> endobj Get a printable copy (PDF file) of the complete article (149K), or click on a page image below to browse page by page. %%EOF Thi s comparison was made first over a 10-week period but the animals were maintained in This handbook attempts to provide a basic guide to anaesthesia for research workers and animal technicians. Basic types of establishments for animal keeping are breeding / supply establishments and user establishments. Mouse stocks and breeding methods were as de-scribed by Bruce & Emmens (1948). Agricultural biotechnology is the term used in crop and livestock improvement through biotechnology tools. INSTITUTE FOR LAbORATORy ANIMAL RESEARCH PUbLICATIONS. The most important item on a rodent breeding bin is the cage ID/breeding record card. Overview of Animal Breeding Fall 2008 1 Required Information Successful animal breeding requires 1. the collection and storage of data on individually identi ed animals; and 2. complete pedigree information about the sire and dam of each animal. Full text Full text is available as a scanned copy of the original print version. used by all persons responsible for laboratory animals and particularly by licensees and others now working under the authority of the Animals (Scientific Procedures) Act, 1986. Part 1: Organizational aspects of a plant breeding programme 197 organizational issues limit the freedom of the breeder in terms of breeding strategies (for example, the choice of testing the breeding material under a given level of inputs). Some, such as selective breeding or exposure to I n a first experi-ment, diet 39 was compared with diet 32, the highly effective breeding diet described in the above paper (see Table 1). Mouse stocks and breeding methods were as de-scribed by Bruce & Emmens (1948). Similarly, the Institute of Several sections of the guidelines have yet to be finalised, but the Councils are now issuing those relating to housing and care of laboratory animals. The reproductive system of the fowl, however, differs in form and function from the other domestic animals covered in this lesson. Animal Breeding Principles and Practice in the Philippine Context, Orville L. Bondoc, 2008, Science, 386 pages. Animal Handling Techniques 1. CPCSEA Guidelines for Laboratory Animal Facility - 2015 61 -96 8. Breeding of and Experiments on Animals (Control and Supervision) Rules, 2006 45 -48 6. A. Breeding may specifically refer to: Breeding in the wild, the natural process of reproduction in the animal kingdom Animal husbandry, through selected specimens such as mices ,rats dogs, horses, and rabbits 5Department of Pharmacology Thi s comparison was made first over a 10-week period but the animals were maintained in Many of the techniques used are poorly understood and produce unpredictable results. 3694 0 obj <>stream In natural mating a breeding male is actually used for mating with the females. In fowl, they also secrete the seminal fluid. Generations: P1 x P2 F1 F2 Too much inbreeding, beyond S6, may be deleterious Year 1 Year 2 Year 3. Breeding System. Animal breeding is a branch of animal science that addresses the evaluation (using best linear unbiased prediction and other methods) of the genetic value (estimated breeding value, EBV) of livestock. Inbreeding may be explained by taking an example of cows and bulls. Who Should Read This Policy All investigators and ACP personnel who run breeding colonies or participate in the activities of a breeding colony. animal genetic resources to provide evidence to inform policy debates. 1. . breeding animals), dogs, and other social species were individually housed. of the penis. %PDF-1.6 %���� Furthermore, processes Methods of Animal Breeding: Two methods of animals breeding are: inbreeding and out breeding, based mainly on breeding work with cattle. are essential to animal breeding and lead to the acquisition of. Rose 6 1.1 Introduction 6 1.2 Minimisation of pain, distress, fear and anxiety 6 1.3 Methods of euthanasia 9 1.4 Special considerations with the age of the animal 12 1.5 Signs of death 14 1.6 Disposal of carcases 15 FELASA has published recommendations for the HM of rodent and rabbit colonies in breeding and experimental units (Nicklas et al. 0 females in a week. • The book covers the discipline of animal breeding from its history, quantitative genetic principles, selection, mating systems and the breeding methods … Methods of Mating Livestock: The two method of mating livestock breeding is natural and artificial. Random breeding methods are used to maintain outbred stock. A PDF is a digital representation of the print book, so while it can be loaded into most e-reader programs, it doesn't allow for resizable text or advanced, interactive functionality. h�bbd```b``� "��H��`M��&���k�����������5�T� ��@�� �i��d/��6��$�uAl�8 �4�Ė��>������&H��L�?×�� ��b In 1985, Congress enacted three laws that dealt with labora- ... Charles River Breeding Laboratories, Inc. Wilmington, MA Earle W. Brauer Revlon Research Center, Inc. ... of alternative methods to animal research, experi-mentation, and testing” from the Chairman of … offers tools to enhance and facilitate the application of both. Some of these animals may suffer severe, even lethal unexpected effects, such as the development of tumours, brain defects, limb The primary enclosure provides the limits of the animal’s immediate environment. Animals (Scientific Procedures) Act, 1986 and associated guidelines, EU Directive 2010/63/EU for animal experiments, or the National Institutes of Health guide for the care and use of Laboratory animals (NIH Publications No. MEENAKSHI M.Sc. Conventional breeding techniques would require that a field Animals (Scientific Procedures) Act, 1986 and associated guidelines, EU Directive 2010/63/EU for animal experiments, or the National Institutes of Health guide for the care and use of Laboratory animals (NIH Publications No. appropriate breeding schemes, weaning ages, and methods for identification of individual animals. Reproduction and Breeding Techniques for Laboratory Animals. . Large numbers of animals may be required to maintain a breeding colony. It is not intended to be a comprehensive text on animal anaesthesia, but concentrates on those areas that are of greatest practical importance when anaesthetizing laboratory animals. Backcross. One is to obtain licence from the Home Department for using them on experimental purposes. Inbreeding: When breeding is between animals of the same breed for 4-6 genera­tions, it is called inbreeding. System of breeding. Normally, breeds are chosen that have complementary traits that will enhance the offsprings’ economic value. Similarly, the Institute of Basic types of establishments for animal keeping are breeding / supply establishments and user establishments. 1. Selection of breeding animals. … It rotates and sprays semen during mating. Large numbers of animals may be required to maintain a breeding colony. Rats respond to considerate and skilful handling and time and effort spent here will pay dividends during the course of the experiment in the form of more relaxed animals and in some cases better and more reproducible experimental results. ... Full text views reflects PDF downloads, PDFs sent to Google Drive, Dropbox and Kindle and HTML full text views. Stephen A. In natural mating a breeding male is actually used for mating with the females. The only advantage of following a commercial crop on station is that a commercial crop is 7 (With 1 Figure in the Text) The high requirement of vitamin C by the guinea-pig is difficult to satisfy in a pelleted diet. quantitative and molecular breeding methods. Without these two pieces of information little genetic change can be made in a pop-ulation. It is not intended to be a comprehensive text on animal anaesthesia, but concentrates on those areas that are of greatest practical importance when anaesthetizing laboratory animals. These include genetics, statistics, reproductive physiology, computer science, and molecular genetics. Rose 6 1.1 Introduction 6 1.2 Minimisation of pain, distress, fear and anxiety 6 1.3 Methods of euthanasia 9 1.4 Special considerations with the age of the animal 12 1.5 Signs of death 14 1.6 Disposal of carcases 15 Laboratory animals in most countries are protected by the Law “Cruelty to Animals Act”. Recognition and Alleviation of Pain in Laboratory Animals (2009) Scientific and Humane Issues in the Use of Random Source Dogs and Cats for Research (2009) Recognition and Alleviation of Distress in Laboratory Animals (2008) Toxicity Testing in the 21st Century: A Vision and a Strategy (2007) … animal products such as urine, dander and serum by using long-necked, non-allergic gloves, laboratory coats and adequate respiratory protective equipment, (b) avoidance of wearing street clothes while working with animals as well as (c) leaving work clothes at the workplace, should be taken. Testicles – As in the other animals, sperm and hormones are produced in the testicles. Breeding Strategies for Maintaining Colonies of Laboratory Mice A Jackson Laboratory Resource Manual This manual describes breeding strategies and techniques for maintaining colonies of laboratory mice. improve plants, trees or animals, or develop microorganisms for specific uses. Laboratory Animals, 2002), with the intention of harmonizing HM pro-grammes. Generations: P1 x P2 F1 F2 S1 families if self pollinated F3 if intermated Year 1 Year 2 Year 3. Laboratory quality standards and their implementation  World Health Organization. The domestic mouse, Mus musculus and related subspecies (see Mice and Rats as Laboratory Animals), is popular as a mammalian research model because of its small size, adaptability, docility, low husbandry costs, fecundity, well-defined health and genetic backgrounds, and relative ease of genetic manipulation.The development of genetic engineering techniques of inserting … Federal Regulations and The Guide for the Care and Use of Laboratory Animals require appropriate management and housing for breeding. �|ÚŸT³MÙ ³cä$60qzòş�j¦#§â�¾2B©’�Ÿ6�e~¤à'×wÀ¬ù‡Ğ–ì0œO‘¦î�ó¨è :†&�¤š8��M>x �N:?ôÑæ°ÏT¤×éP=‚bÙ%M%ß …Ú“. Coronavirus: Find the latest articles and preprints ... Get a printable copy (PDF file) of the complete article (149K), or click on a page image below to browse page by page. endstream endobj startxref Basically, there are two methods of breeding which are as follows: Inbreeding : Breeding of the related animals as sire ... inbreeding is intentionally practiced to create genetic uniformity of laboratory stocks and to produce stocks for crossing (animal and plant breeding). Total number of HTML views: 0. A NOTE ON THE BREEDING OF GUINEA-PIGS WITHOUT FRESH GREEN FOOD BY H. M. BRUCE From the National Institute for Medical Research, London, N.W. These techniques have been developed and used by The Jackson Laboratory for nearly 80 years. Animal Breeding Principles and Practice in the Philippine Context, Orville L. Bondoc, 2008, Science, 386 pages. animals. . animals should be handled regularly and fully famil- iarized with the methods of restraint to be used later. accordance with the U.K. appropriate breeding schemes, weaning ages, and methods for identification of individual animals. . But these techniques are 'artificial' and they deprive animals of natural mating behaviour and negatively affect the animals' welfare and integrity. Genetic evaluation of individual animals in a breeding population, selection of the best individuals for traits of importance in some sense (adaptation, production, economic), followed by mating of selected individuals to generate the next generation of animals. Humanity has been modifying domesticated animals to better suit human needs for centuries. 3682 0 obj <>/Filter/FlateDecode/ID[<32FBC5F92B59443492AA5618E7523721><38EEA92E5768D94AA9E883AA2B98B893>]/Index[3658 37]/Info 3657 0 R/Length 116/Prev 1492729/Root 3659 0 R/Size 3695/Type/XRef/W[1 3 1]>>stream Hundreds of animals may be 'created' in an attempt to obtain a transgenic individual with a particular desired set of traits. The Jackson Laboratory Handbook on Genetically Standardized Mice . B. The goal of that course was to train students to program new ideas in animal breeding. This monograph will focus only on agricultural crop biotechnology. The exact procedure for rodent breeding for investigators is performed according to instructions in the individual animal use protocols. accordance with the U.K. Selecting for breeding animals with superior EBV in growth rate, egg, meat, milk, or wool production, or with other desirable traits has revolutionized livestock production throughout the … Akodon molinae (Rodentia Cricetidae), a new laboratory animal: breeding, management and reproductive performance breeding animals), dogs, and other social species were individually housed. To comply with the Animal Welfare Ordinance and avoid mishandling of animals in research. establish a laboratory animal health monitoring (HM) programme as an integrated part of any quality assur-ance system. 1st Year ANIMAL HANDLING TECHNIQUES 2. OBJECTIVES To provide basic concept of animal handling to new user. Animal breeding the modern approach : a textbook for consultants, farmers, teachers and for students of animal breeding, Keith Hammond, Hans-Ulrich Graser, Alex McDonald, 1992, Animal breeding, 257 pages. Methods. I routinely witnessed ... for the Care and Use of Laboratory Animals, published in 2011, embraces this view (albeit without the regulatory force of the Animal Welfare Act). This handbook attempts to provide a basic guide to anaesthesia for research workers and animal technicians. The macroenvironment is the physical environment of the secondary enclosure (suc h as an animal holding room, a barn, etc.). Yorkshires have acceptable rates of gain in muscle mass and produce large … The report concludes that: Key technologies relating to animal breeding have a long history and breakthroughs typically involve new methods or technologies rather than depending on genetic material per se; domestic animals (2). domestic animals (2). Observations on the feeding of guinea-pigs - Volume 45 Issue 1. Selection of males is less intense in this as a bull can be used for mating only 2-3 times, i.e. FELASA has published recommendations for the HM of rodent and rabbit colonies in breeding and experimental units (Nicklas et al. 2. Animal breeding - Animal breeding - Breeding systems: Crossbreeding involves the mating of animals from two breeds. The health and well-being of the animals depend on the care, human attitude of the animal-keepers (staff) of the animal house. Inbreeding has not been initiated; instead, systematic mating of cousins is used in an attempt to preserve heterozygosity, since this is thought to be better than random mating in smaller … The other method is artificial insemination. Feeding and breeding of laboratory animals III. … Reilly and M.A. 1st Year ANIMAL HANDLING TECHNIQUES 2. females in a week. This card records the breeding of 1-2 female rodents per cage. Several sections of the guidelines have yet to be finalised, but the Councils are now issuing those relating to housing and care of laboratory animals. Biotechnology encompasses a number of tools and elements of conventional breeding techniques, These range from conventional breeding techniques (CBT), established techniques of genetic modification (ETGM) and a growing number of what are commonly called new breeding techniques (NBT). The primary enclosure provides the limits of the animal’s immediate environment. Vertebrate Animals Used in Testing, Research, and Training. Selection methods. Georgia in 1997. Reilly and M.A. animals should be handled regularly and fully famil- iarized with the methods of restraint to be used later. Estimates of repeatability obtained from this study were 0.29, 0.26, 0.22, 0.38, 0.41, and 0.74 for BWs of chickens at 1 day, 4, 8, 9, 10 and 16 weeks of age respectively (Table 9). Regional Office for the Western Pacific (‎ Manila : WHO Regional Office for the Western Pacific , 2011 )‎ But these techniques are 'artificial' and they deprive animals of natural mating behaviour and negatively affect the animals' welfare and integrity. An additional point of concern are the reproduction techniques used in conventional breeding. establish a laboratory animal health monitoring (HM) programme as an integrated part of any quality assur-ance system. The programme provides sound training in these basic subjects that. Guidelines on the Regulation of Scientific Experiments on Animals 49 -60 7. I n a first experi-ment, diet 39 was compared with diet 32, the highly effective breeding diet described in the above paper (see Table 1). Artificial insemination (AI) and embryo transfer (ET) are commonplace in conventional animal breeding. Methods of Mating Livestock: The two method of mating livestock breeding is natural and artificial. The number of animals can only be approximated in advance because it is impossible to predict the exact number and sex of offspring. Programming was in Fortran because Fortran programs are relatively easy for numerical problems, and many existing packages in animal breeding still useful at that time were written in Fortran. e���n�On�nҌ.i�EEܱ���]���wg/_��4�Nٍ� ����O�xGmR������Itk>c. II. use of laboratory animals. Section 1 Animal Welfare Considerations J.S. Conventional breeding techniques would require that a field III. Breeding Strategies for Maintaining Colonies of Laboratory Mice A Jackson Laboratory Resource Manual Th is manual describes breeding strategies and techniques for maintaining colonies of laboratory mice. 345 . Genetic evaluation of individual animals in a breeding population, selection of the best individuals for traits of importance in some sense (adaptation, production, economic), followed by mating of selected individuals to generate the next generation of animals. 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